UC Irvine Medical Scientist Training Program

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Autumn Ivy

Undergraduate	California State University, Los Angeles
Year of Entry into UCI MSTP	2004
Research Interests	neurodevelopment, HPA axis, corticotropin-releasing hormone, learning and memory
Hobbies and Interests	Dance, Movies, Musicals, Reading, spending time with family
Hometown	Inglewood, CA
Website

Lab Rotations Completed

Lab Advisor	Tallie Z. Baram
Department	Anatomy and Neurobiology
Academic Quarter	Summer 2006 -
Project Topic	Molecular mechanisms by which chronic early-life stress programs the hippocampus
Project Abstract	Early-life chronic stress can produce long-lasting changes in hippocampal development, which may predispose to the onset of cognitive or other psychopathological disorders. Neuromodulators released in response to stressors, especially corticotropin-releasing hormone, have been shown to influence the growth and pruning of hippocampal dendrites. Furthermore, a novel model of early-life chronic stress used by the Baram lab leads to cognitive decline in middle-aged rats, as well as reduce the number of apical dendrites in CA3 hippocampal neurons. My project aims to elucidate the role of CRH and other mediators in the mechanism of this cognitive decline, by characterizing their expression in the hippocampus of rats following early-life chronic stress.

PUBLICATIONS

Chen MJ, Ivy AS, Russo-Neustadt AA., Nitric oxide synthesis is required for exercise-induced increases in hippocampal BDNF and phophatidylinositol 3' kinase expression.. Brain Research Bulletin(2006), Jan 15; 68(4):257-68..
Russo-Neustadt AA, Alejandre H, Garcia C, Ivy AS, Chen MJ., Hippocampal brain-derived neurotrophhic factor expression following treatment with reboxetine, citalopram, and physical exercise.. Neuropsychopharmacology(2004), Dec; 29(12):2189-99.
Ivy AS, Rodriguez FG, Garcia C, Chen MJ, Russo-Neustadt AA., Noradrenergic and serotonergic blockade inhibits BDNF mRNA activation following exercise and antidepressant.. Pharmacology, Biochemistry and Behavior(2003), Apr;75(1):81-88.
Ivy AS, Brunson KL, Sandman C, and Baram TZ., "Dysfunctional nurturing behavior in rat dams with limited access to nesting material: a clinically relevant model for early-life stress". Neuroscience(2008), 154: 1132-1142.

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