UC Irvine Medical Scientist Training Program

Jaime Rosa

Undergraduate	UCLA
Year of Entry into UCI MSTP	2002
Research Interests	pharmacology, physiology, pediatrics.
Hobbies and Interests	basketball, foreign languages and cultures.
Hometown	Hong Kong, China
Website

Lab Rotations Completed

Lab Advisor	Pietro Galassetti, M.D., Ph.D.
Department	Dept of Pharmacology, SOM. General Clinical Research Center, SOM.
Academic Quarter	Fall 2005-present.
Project Topic	Effect of antecedent stress on adaptive response to exercise in children with metabolic disorders (type 1 diabetes mellitus and metabolic syndrome).
Project Abstract	As exercise is widely held to help prevent cardiovascular disease, it is strongly encouraged in high-risk conditions such as metabolic disorders (particularly type 1 diabets mellitus and metabolic syndrome). However, exercise also stimulates secretion of inflammatory cytokines (with individual kinetics depending on exercise type, duration, intensity) which, in the chronic low-grade inflammatory state of metabolic disorder, may limit its overall beneficial effects. Determining optimal exercise regimens for children with metabolic disorders, therefore, requires the deep understanding of all molecular adaptations to exercise, including kinetic profiles of immunomodulatory factors. Intense, repeated exercise (simulating spontaneous activity in children) induced a charcteristic secretion profile of inflammatory cytokines with differing individual kinetics. This underscores the necessity of clarifying magnitude and timing of exercise-induced changes in immunomodulatory cytokines, in order to optimize exercise strategies in children with metabolic disorders.

PUBLICATIONS

(Abstract) Rosa JS, Oliver SR, Pontello AM, Flores RL, Zaldivar FP, Galassetti PR, Kinetics of inflammatory mediators during and following exercise in diabetic and non-diabetic children. American Diabetes Association 67th Scientific Sessions; 21st Annual National M.D./Ph.D. Student Conference(2007), poster presentations and catalog publications.
(Abstract) Rosa JS, Galassetti PR, Oliver SR, Pontello AM, Flores RL, Zaldivar FP, Mitsuhashi M, Changes in COX-2 and HSP-70 mRNA following exercise in diabetic and non-diabetic children. Experimental Biology Annual Meeting(2007), poster presentation and catalog publication.
(Abstract) Galassetti PR, Rosa JS, Flores RL, Pontello AM, Larson JK, Mitsuhashi M, Reduced baseline and post-exercise leukocyte mRNA expression of inflammatory cytokines in type 1 DM children during ex-vivo incubation. American Diabetes Association 66th Scientific Sessions(2006), poster presentation and catalog publication.
(Abstract) Galassetti PR, Rosa JS, Zaldivar FP, Pontello AM, Flores RL, Mitsuhashi M, Exercise induces leukocyte mRNA expression of inflammatory mediators in type 1 DM children. American Diabetes Association 66th Scientific Sessions(2006), catalog publication.
(Abstract) Galassetti PR, Flores RL, Larson JK, Zaldivar FP, Barnett M, Rosa JS, Prolonged effect of hyperglycemia on circulating pro-inflammatory cytokines in children with type 1 diabetes. American Diabetes Association 66th Scientific Sessions(2006), oral presentation and catalog publication.
(Abstract) Rosa JS, Flores RL, Pontello AM, Zaldivar FP, Culler FL, Galassetti PR, Pro-/anti-inflammatory cytokine kinetics during acute exercise in type 1 DM children. American Diabetes Association 66th Scientific Sessions(2006), catalog publication, 2006.
(Abstract) Rosa JS, Oliver SR, Pontello AM, Flores RL, Zaldivar FP, Galassetti PR, Systemic cytokine changes in children during prolonged intense exercise. American College of Sports Medicine 54th Annual Meeting(2007), poster presentation and catalog publication.
(Abstract) Galassetti PR, Oliver SR, Midyett J, Flores RL, Pontello AM, Rosa JS, Blake DR, Exhaled volatile organic compounds during hyperglycemia and euglycemia/hyperinsulinemia in healthy males. American Diabetes Association 67th Scientific Sessions(2007), poster presentation and catalog publication.
(Abstract) Oliver SR, Flores RL, Pontello AM, Rosa JS, Zaldivar FP, Galassetti PR, Physiological hyperinsulinemia, independent of hyperglycemia, suppresses sCD40L, EGF, and IP-10 in healthy adults. American Diabetes Association 67th Scientific Sessions(2007), oral presentation and catalog publication.
(Abstract) Galassetti PR, Rosa JS, Oliver SR, Flores RL, Pontello AM, Graf SC, Mitsuhashi M, Increased ex-vivo leukocyte mRNA expression of inflammatory cytokines/chemokines in type 1 diabetic children. American Diabetes Association 67th Scientific Sessions(2007), poster presentation and catalog publication.
(Abstract) Rosa JS, Oliver SR, Flores RL, Mitsuhashi M, Pontello AM, Graf SC, Galassetti PR, Exercise-induced leukocyte response and changes in VEGF mRNA expression in healthy and type 1 diabetic children. American Diabetes Association 67th Scientific Sessions(2007), poster presentation and catalog publication.
(Abstract) Oliver SR, Rosa JS, Lee JS, Pontello AM, Graf SC, Flores RL, Galassetti PR, Oxidative stress mechanisms during intermittent exercise in normal and overweight children. American College of Sports Medicine 54th Annual Meeting(2008), poster presentation and catalog publication.
(Abstract) Rosa JS, Schwindt CD, Oliver SR, Leu S, Zaldivar FP, Galassetti PR, Rapid post-exercise correction of neutrophilia in healthy, type 1 diabetic, obese, and asthmatic Children. American College of Sports Medicine 54th Annual Meeting(2008), poster presentation and catalog publication.
(Abstract) Lee JS, Oliver SR, Rosa JS, Pontello AM, Graf SC, Galassetti PR, Comparison of physical fitness in type 1 diabetic and healthy children matched by age, gender, and BMI. Experimental Biology Annual Meeting(2008), poster presentation and catalog publication.
(Abstract) Rosa JS, Oliver SR, Lee JS, Flores RL, Ibardolaza M, Zaldivar FP, Galassetti PR, Circulatory interleukin-6 is elevated in overweight compared to healthy and type 1 diabetic children. Experimental Biology Annual Meeting(2008), poster presentation and catalog publication.
(Abstract) Rosa JS, Oliver SR, Flores RL, Leu S, Pontello AM, Galassetti PR, Rapid post-exercise correction of neutrophilia in healthy, type 1 diabetic, obese, and asthmatic children. American College of Sports Medicine 54th Annual Meeting(2008), poster presentation and catalog publication.
(Abstract) Lee JS, Newcomb RL, Blake DR, Meinardi S, Midyett JR, Rosa JS, Galassetti PR, Predictive models for plasma glucose using exhaled volatile organic compounds. American Diabetes Association 68th Scientific Sessions(2008), poster presentation and catalog publication.
(Abstract) Oliver SR, Rosa JS, Pontello AM, Flores RL, Zaldivar FP, Bachman G, Galassetti PR, Dyslipidemia and increased oxidative stress in normo-insulinemic overweight children. American Diabetes Association 68th Scientific Sessions(2008), oral presentation and catalog publication.
(Abstract) Rosa JS, Oliver SR, Flores RL, Leu S, Pontello AM, Graf SC, Galassetti PR, Elevated baseline IL-6 and altered IL-6 response to exercise in overweight compared to healthy and type 1 diabetic children. American Diabetes Association 68th Scientific Sessions(2008), poster presentation and catalog publication.
Rosa JS, Schwindt CD, Oliver SR, Leu SY, Flores RL, Galassetti PR, Rapid post-exercise correction of neutrophilia in healthy, type 1 diabetic, obese, and asthmatic children. Exercise Science(2008), submitted.
(Abstract) Rosa JS, Mitsuhashi M, Flores RL, Pontello AM, Barnett M, Zaldivar FP, Galassetti PR, Elevated ex-vivo gene expression of 9 inflammatory mediators in leukocytes of type 1 diabetic compared to overweight and healthy children. American Diabetes Association 68th Scientific Sessions(2008), poster presentation and catalog publication.
Rosa JS, Oliver SR, Mitsuhashi M, Flores RL, Pontello AM, Zaldivar FP, Galassetti PR, Altered kinetics of IL-6 and other inflammatory mediators during exercise in children with type 1 diabetes. Journal of Investigative Medicine(2008), in press.
Rosa JS, Oliver SR, Flores RL, Graf SC, Pontello AM, Ibardolaza M, Zaldivar FP, Galassetti PR, Kinetic profiles of 18 systemic pro- and anti-inflammatory mediators during and following exercise in children. Journal of Pediatric Endocrinology & Metabolism(2007), 20(12): 1293-1305.
Rosa JS, Flores RL, Oliver SR, Pontello AM, Zaldivar FP, Galassetti PR, Sustained IL-1α, IL-4, IL-6 elevations following correction of hyperglycemia in children with type 1 diabetes mellitus. Pediatric Diabetes(2008), 9(1):9-16.